Temp file error! Non deleting these files. Need help?

I generally run %temp% from RUN option of START menu & delete theose file. But from few days i have noticed that some of them are non-deleteable. I tried to delete them in SAFE MODE also. There first time though are deleted but in normal mode they are remaining same. The files are like jar_cache28860.tmp & newtb1handler & toolbox_healer28854 and a blank folder i.e., WPDNSE. I want to delete all these files. How can i?